Living labs to monitor and mitigate carcinogenic substances in and originating from soils: Evaluating their effects on human cancer risks

Expected Outcome: Activities under this topic will directly progress towards the goal of the Mission Soil to set up 100 living labs and lighthouses to lead the transition to healthy soils by 2030. Activities will also contribute to the goal of the Cancer Mission, i.e.: ‘to improve the lives of more than 3 million people by 2030, through prevention, cure and for those affected by cancer including their families, to live longer and better’. Activities should also contribute to meeting the European Green Deal ambitions and targets and more specifically those of the EU Biodiversity Strategy for 2030 , the EU Soil Strategy for 2030, the proposal for a Soil Monitoring and Resilience Directive , the Zero Pollution Action Plan , the Europe's Beating Cancer Plan , the One Health approach, the European Health Data Space , the Chemicals Strategy for Sustainabilit y, the European Chemicals Industry Action Plan , as well as to the Sustainable Development Goals [1] . Project results are expected to contribute to all the following expected outcomes: increased capacities for participatory, interdisciplinary and transdisciplinary research and innovation to co-create, and co-implement economically viable soil health solutions tailored to soils contaminated with or at risk of contamination by carcinogenic substances; enhanced understanding of the environmental pathways through which these substances affect humans and the food chain, and the links (drivers and processes) between carcinogenic substances [2] in soil and cancer incidence, mortality and prevalence in humans. Scope: Environmental and occupational cancer risks are estimated to contribute to over 10% of the total cancer burden in Europe, with soil pollution by carcinogenic substances, such as PFAS, and heavy metals like arsenic and cadmium, posing significant concerns for human and environmental health [3] . However, the complex relationships between land management practices, soil parent material, soil properties, and presence of carcinogenic substances remain largely unknown. Moreover, significant knowledge gaps exist regarding biomonitoring, the bioaccumulation and transfer processes of soil pollutants into the food chain, water, and air, the pathways of human exposure and the impact of such exposure on cancer incidence, mortality and prevalence. Projects under this topic are intended to expand and complement the network of Mission Soil living labs and lighthouses initiated with projects funded under Work Programmes 2023, 2024 and 2025 of the Mission Soil, with the aim of gradually establishing 100 living labs …